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45 - PHR - Pharmaceutical Sciences


PHR 114 - Introduction to Pharmacokinetics

Code Start Date Duration Venue
PHR 114 17 October 2022 5 Days Istanbul Registration Form Link
PHR 114 12 December 2022 5 Days Istanbul Registration Form Link
Please contact us for fees

 

Course Description

The course presents fundamental pharmacokinetic concepts in a manner that will allow participants without a specific pharmacokinetic background to apply these principles to their work. The emphasis will be on conceptual understanding with supporting methods to encourage active learning and long-term retention. Basic concepts of clearance, volume of distribution, and bioavailability will be presented and applied to absorption, distribution, metabolism, and excretion of drugs.

This course gives a basic understanding of pharmacokinetics and pharmacodynamics to either further their own work or to more effectively interact with scientists involved in pharmacokinetic and drug delivery research. Concepts covered in this course are essential in the evaluation of traditional dosage forms and innovative medical delivery systems and devices.

 

Course Objectives

  • Understanding the requirements for ADME
  • Knowing about PK/TK, and DM studies conducted to select the optimal drug discovery lead
  • Supporting first-in-human clinical trials (preclinical studies)
  • Comparing metabolism profiles from animal models to humans (nonclinical / clinical evaluations)

Who Should Attend?

  • Personnel in the pharmaceutical and biotechnology industries
  • Contract research organizations (CROs) who need to understand the principles and requirements for ADME 
  • Personnel working in drug discovery and the preclinical/nonclinical and clinical development processes
  • Nonclinical and clinical scientists and managers
  • Project team leaders at pharmaceutical companies and related industries
  • Those who seek information to support submissions to regulatory authorities

Course Details/Schedule

Day 1

  • Pharmacokinetics - definitions and terminology
  • Physiological aspects of drug absorption, distribution and elimination
  • Ideal pharmacokinetic parameters of a new drug preparation.
  • Assessment of pharmacokinetic parameters

Day 2

  • Assessment of rate and extent of drug absorption; bioavailability
  • How do we optimize PK for new compounds
  • Reasons behind why some drug candidates fail   
  • Processes involved in PK

Day 3

  • Absorption
  • PK study examples and case studies
  • Distribution
  • Whole-body autoradiography example
     

 

Day 4

  • Metabolism
  • Discussion
  • Excretion

Day 5

  • Multiple Dosing
  • Discussion
  • Allometric scaling  between species